LABOTEST-BB LT01147747
4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE
CAS: 86030-08-2
Molecular Formula: C12H8ClNO4S
LABOTEST-BB LT01147747 - Names and Identifiers
LABOTEST-BB LT01147747 - Physico-chemical Properties
| Molecular Formula | C12H8ClNO4S |
| Molar Mass | 297.71 |
| Melting Point | 115 °C |
| Solubility | Soluble in DMSO (30 mg/ml) |
| Appearance | solid |
| Color | White to off-white |
| Storage Condition | Sealed in dry,Room Temperature |
| Stability | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 2 months. |
| In vitro study | BTB-1 blocks the motility of Kif18A in a reversible manner. BTB-1 inhibits Kif18A in an adenosine triphosphate (ATP)-competitive but microtubule-uncompetitive manner and slows down the progression of cells through mitosis. 100 μM BTB-1 does not significantly inhibit any of the other tested mitotic kinesins. BTB-1 competes with ATP for Kif18A binding only when the motor-protein is associated with its pseudosubstrate microtubules. HeLa cells treated with BTB-1 accumulate in mitosis in a dose-dependent manner. BTB-1 shows cell toxicity with an EC 50 values of 35.8 μM. HeLa cells treated with 50 μM BTB-1 reveals severe defects in spindle morphology and chromosome alignment. Treatment with high concentrations of BTB-1 does not result in elongated spindles. |
LABOTEST-BB LT01147747 - Risk and Safety
| Risk Codes | 36/37/38 - Irritating to eyes, respiratory system and skin. |
| Safety Description | S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. |
| Hazard Class | IRRITANT |
LABOTEST-BB LT01147747 - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 3.359 ml | 16.795 ml | 33.59 ml |
| 5 mM | 0.672 ml | 3.359 ml | 6.718 ml |
| 10 mM | 0.336 ml | 1.679 ml | 3.359 ml |
| 5 mM | 0.067 ml | 0.336 ml | 0.672 ml |
Last Update：2024-01-02 23:10:35
LABOTEST-BB LT01147747 - Reference Information
| biological activity | BTB-1 is a novel, reversible and selective inhibitor of mitotic motor protein Kif18A, the IC50 value was 1.69 μm. |
| Target | Value |
| Kif18A (Cell-free assay) | 1.69 μM |
Last Update：2024-04-10 22:29:15
Supplier List
Spot supply
Product Name: BTB-1 Visit Supplier Webpage Request for quotationCAS: 86030-08-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Visit Supplier Webpage Request for quotationCAS: 86030-08-2
Tel: +86-400-900-4166
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Spot supply
Product Name: BTB-1 Visit Supplier Webpage Request for quotationCAS: 86030-08-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Visit Supplier Webpage Request for quotationCAS: 86030-08-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Spot supply
Product Name: BTB-1 Visit Supplier Webpage Request for quotationCAS: 86030-08-2
Tel: 609-228-6898
Email: sales@medchemexpress.com
tech@medchemexpress.com
Mobile: 609-228-6898
Spot supply
Product Name: 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Visit Supplier Webpage Request for quotationCAS: 86030-08-2
Tel: +86-400-900-4166
Email: product@acmec-e.com
Mobile: +86-18621343501
QQ: 2881950922
Wechat: 18621343501
WhatsApp: +86-18621343501
Spot supply
Product Name: BTB-1 Visit Supplier Webpage Request for quotationCAS: 86030-08-2
Tel: +86-18821248368
Email: Int06@meryer.com
Mobile: +86-18821248368
QQ: 495145328
WhatsApp: +86-18821248368
Spot supply
Product Name: 4-CHLORO-2-NITRO-1-(PHENYLSULFONYL)BENZENE Visit Supplier Webpage Request for quotationCAS: 86030-08-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
View History
LABOTEST-BB LT01147747
5-Hydroxy Rosiglitazone-d4
Tricyclo[3.3.1.13,7]decane-1-a acid, .alpha.-[[(1,1-dimethyleth no]-3-hydroxy-, (.alpha.S)-
2-methyl-2-(4-nitroimidazol-1-yl)propionic acid methyl ester
Ammonium di-molybdate
[1,3-双(2,4,6-三甲基苯基)-2-咪唑烷亚基][2-[[(2-甲基苯基)亚氨基]甲基]苯酚基](3-苯基-1H-茚-1-亚基)氯化钌
Pitstop 2
TOSLAB 853910
N-三苯甲基-4,5,6,7-四氢噻吩并[3,2-C]吡啶
cadmium ion chromatography std sol. fluka
5-Hydroxy Rosiglitazone-d4
Tricyclo[3.3.1.13,7]decane-1-a acid, .alpha.-[[(1,1-dimethyleth no]-3-hydroxy-, (.alpha.S)-
2-methyl-2-(4-nitroimidazol-1-yl)propionic acid methyl ester
Ammonium di-molybdate
[1,3-双(2,4,6-三甲基苯基)-2-咪唑烷亚基][2-[[(2-甲基苯基)亚氨基]甲基]苯酚基](3-苯基-1H-茚-1-亚基)氯化钌
Pitstop 2
TOSLAB 853910
N-三苯甲基-4,5,6,7-四氢噻吩并[3,2-C]吡啶
cadmium ion chromatography std sol. fluka